Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294511 | 1.00 | DHODH (0.49) | DHODHCFTRSCN8AAKR1C3AKR1C2 | |
| SCHEMBL30294684 | 0.91 | CFTR (0.48) | DHODHCFTRSCN8AAKR1C3AKR1C2 | |
| SCHEMBL22852810 | 0.91 | CFTR (0.48) | DHODHCFTRSCN8AAKR1C3AKR1C2 | |
| SCHEMBL30294477 | 0.90 | DHODH (0.59) | DHODHSCN8AAKR1C3AKR1C2KDM4E | |
| SCHEMBL22853392 | 0.90 | DHODH (0.59) | DHODHSCN8AAKR1C3AKR1C2KDM4E | |
| SCHEMBL22853416 | 0.89 | CFTR (0.46) | DHODHCFTRSCN8AKDM4EMAPT | |
| SCHEMBL30294604 | 0.89 | CFTR (0.46) | DHODHCFTRSCN8AKDM4EMAPT | |
| SCHEMBL22833864 | 0.86 | CFTR (0.50) | DHODHCFTRSCN8ATAS2R14SCN10A | |
| SCHEMBL29383454 | 0.86 | CFTR (0.50) | DHODHCFTRSCN8ATAS2R14SCN10A | |
| SCHEMBL22453439 | 0.84 | TUBB4A (0.46) | DHODHCFTRAKR1C3AKR1C2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |