Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294611 | 1.00 | KDM4E (0.44) | KDM4ELMNAMRGPRX4CYP1A2CYP2C9 | |
| SCHEMBL29382578 | 0.87 | KDM4E (0.46) | KDM4ELMNAMRGPRX4CYP1A2CYP2C9 | |
| SCHEMBL22833395 | 0.87 | KDM4E (0.46) | KDM4ELMNAMRGPRX4CYP1A2CYP2C9 | |
| SCHEMBL22853132 | 0.84 | TAS2R14 (0.59) | KDM4ECYP2C19TAS2R14 | |
| SCHEMBL30294773 | 0.84 | TAS2R14 (0.59) | KDM4ECYP2C19TAS2R14 | |
| SCHEMBL22852778 | 0.82 | MAP2K2 (0.48) | KDM4ELMNAMRGPRX4CYP1A2CYP2C9 | |
| SCHEMBL30294768 | 0.82 | MAP2K2 (0.48) | KDM4ELMNAMRGPRX4CYP1A2CYP2C9 | |
| SCHEMBL30294404 | 0.81 | MRGPRX4 (0.48) | KDM4ELMNAMRGPRX4MAPTPOLB | |
| SCHEMBL22852785 | 0.81 | MRGPRX4 (0.48) | KDM4ELMNAMRGPRX4MAPTPOLB | |
| SCHEMBL26931183 | 0.81 | KDM4E (0.44) | KDM4ELMNAMRGPRX4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |