Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294352 | 1.00 | KDM4E (0.54) | KDM4EGAAAPAF1RECQLCASP6 | |
| SCHEMBL30294853 | 0.90 | KMT2A (0.51) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL22853031 | 0.90 | KMT2A (0.51) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL22853109 | 0.86 | MRGPRX1 (0.56) | KDM4EGAAKMT2AMEN1LMNA | |
| SCHEMBL30294316 | 0.86 | MRGPRX1 (0.56) | KDM4EGAAKMT2AMEN1LMNA | |
| SCHEMBL22853477 | 0.85 | KCNMA1 (0.56) | KDM4EGAAAPAF1RECQLCASP6 | |
| SCHEMBL30294462 | 0.85 | KCNMA1 (0.56) | KDM4EGAAAPAF1RECQLCASP6 | |
| SCHEMBL30294465 | 0.85 | KCNMA1 (0.56) | KDM4EGAAAPAF1RECQLCASP6 | |
| SCHEMBL22853479 | 0.84 | KDM4E (0.52) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL30294307 | 0.84 | KDM4E (0.52) | KDM4EAPAF1RECQLCASP6CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |