Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294853 | 1.00 | KMT2A (0.51) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL22852839 | 0.90 | KDM4E (0.54) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL30294352 | 0.90 | KDM4E (0.54) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL22853333 | 0.86 | ALDH1A1 (0.46) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL22853102 | 0.85 | KCNMA1 (0.56) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL31521818 | 0.85 | KMT2A (0.53) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL30294527 | 0.85 | KCNMA1 (0.56) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL30294920 | 0.84 | KDM4E (0.46) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL22853100 | 0.84 | KDM4E (0.46) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL30294916 | 0.84 | KDM4E (0.46) | KMT2AMEN1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |