Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294466 | 1.00 | CLCN2 (0.43) | CLCN2MKNK2MAPK3MAPK13MAPK12 | |
| SCHEMBL30294640 | 0.89 | MAPK3 (0.41) | MKNK2MAPK3MAPK13MAPK12MAPK11 | |
| SCHEMBL22853043 | 0.89 | MAPK3 (0.41) | MKNK2MAPK3MAPK13MAPK12MAPK11 | |
| SCHEMBL30294810 | 0.87 | P2RX7 (0.37) | CLCN2MAPK3FTOFABP3FABP4 | |
| SCHEMBL22853008 | 0.85 | CLCN2 (0.47) | CLCN2MKNK2MAPK3MAPK13MAPK12 | |
| SCHEMBL22853004 | 0.85 | FTO (0.47) | CLCN2MKNK2MAPK3MAPK13MAPK12 | |
| SCHEMBL30294418 | 0.85 | FTO (0.47) | CLCN2MKNK2MAPK3MAPK13MAPK12 | |
| SCHEMBL30294338 | 0.85 | CLCN2 (0.47) | CLCN2MKNK2MAPK3MAPK13MAPK12 | |
| SCHEMBL22853352 | 0.83 | DHODH (0.43) | DHODH | |
| SCHEMBL30294359 | 0.83 | DHODH (0.43) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |