Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.44 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 4/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294438 | 1.00 | AKR1C2 (0.46) | AKR1C2AKR1C1P2RX7IGF2BP2DHODH | |
| SCHEMBL22853041 | 0.91 | P2RX7 (0.47) | AKR1C2AKR1C1P2RX7DHODHFFAR4 | |
| SCHEMBL30294697 | 0.91 | P2RX7 (0.47) | AKR1C2AKR1C1P2RX7DHODHFFAR4 | |
| SCHEMBL22853082 | 0.82 | CLCN2 (0.53) | DHODHFTO | |
| SCHEMBL30294669 | 0.82 | CLCN2 (0.53) | DHODHFTO | |
| SCHEMBL22853116 | 0.81 | FFAR4 (0.45) | AKR1C2AKR1C1P2RX7IGF2BP2DHODH | |
| SCHEMBL30294459 | 0.81 | FFAR4 (0.45) | AKR1C2AKR1C1P2RX7IGF2BP2DHODH | |
| SCHEMBL22853208 | 0.81 | KDR (0.42) | P2RX7DHODHKDRBRAF | |
| SCHEMBL30294559 | 0.81 | KDR (0.42) | P2RX7DHODHKDRBRAF | |
| SCHEMBL22853488 | 0.81 | IGF2BP2 (0.50) | P2RX7IGF2BP2DHODHKCNK2KCNK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |