Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | CDC25C | P30307 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294439 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBTDP1NR3C2LMNA | |
| SCHEMBL22853030 | 0.86 | LMNA (0.47) | SMN1; SMN2POLBTDP1NR3C2LMNA | |
| SCHEMBL30294265 | 0.86 | LMNA (0.47) | SMN1; SMN2POLBTDP1NR3C2LMNA | |
| SCHEMBL22852780 | 0.84 | MEN1 (0.43) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL30294497 | 0.84 | MEN1 (0.43) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL22853396 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2POLBTDP1LMNAKDM4E | |
| SCHEMBL30294743 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2POLBTDP1LMNAKDM4E | |
| SCHEMBL30294519 | 0.76 | CDC25B (0.47) | SMN1; SMN2POLBTDP1KDM4EHTT | |
| SCHEMBL13247557 | 0.74 | CDC25B (0.61) | SMN1; SMN2POLBLMNAKDM4ECDC25A | |
| SCHEMBL22853409 | 0.73 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBTDP1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |