Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294498 | 1.00 | SCN10A (0.41) | SCN10ADHODHSORT1P2RX7MAPT | |
| SCHEMBL30294778 | 0.88 | SORT1 (0.46) | SCN10ADHODHSORT1MAPTNPC1 | |
| SCHEMBL22853203 | 0.88 | SORT1 (0.46) | SCN10ADHODHSORT1MAPTNPC1 | |
| SCHEMBL22853062 | 0.88 | DHODH (0.47) | SCN10ADHODHSORT1MAPTNPC1 | |
| SCHEMBL30294556 | 0.88 | DHODH (0.47) | SCN10ADHODHSORT1MAPTNPC1 | |
| SCHEMBL22833774 | 0.87 | SCN10A (0.41) | SCN10ADHODHSORT1MAPTNPC1 | |
| SCHEMBL29382605 | 0.87 | SCN10A (0.41) | SCN10ADHODHSORT1MAPTNPC1 | |
| SCHEMBL22852910 | 0.87 | SORT1 (0.46) | SCN10ADHODHSORT1P2RX7MAPT | |
| SCHEMBL30294376 | 0.87 | SORT1 (0.46) | SCN10ADHODHSORT1P2RX7MAPT | |
| SCHEMBL22853060 | 0.87 | TOP1 (0.47) | DHODHSORT1MAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |