Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 8/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22853062 | 1.00 | DHODH (0.47) | DHODHHDAC6LCKSORT1NPC1 | |
| SCHEMBL22853060 | 0.90 | TOP1 (0.47) | DHODHSORT1NPC1MAPT | |
| SCHEMBL30294610 | 0.90 | TOP1 (0.47) | DHODHSORT1NPC1MAPT | |
| SCHEMBL22853145 | 0.88 | SCN10A (0.41) | DHODHSORT1NPC1MAPTSCN10A | |
| SCHEMBL30294498 | 0.88 | SCN10A (0.41) | DHODHSORT1NPC1MAPTSCN10A | |
| SCHEMBL30294778 | 0.86 | SORT1 (0.46) | DHODHLCKSORT1NPC1MAPT | |
| SCHEMBL22853203 | 0.86 | SORT1 (0.46) | DHODHLCKSORT1NPC1MAPT | |
| SCHEMBL22833774 | 0.84 | SCN10A (0.41) | DHODHSORT1NPC1MAPTSCN10A | |
| SCHEMBL29382605 | 0.84 | SCN10A (0.41) | DHODHSORT1NPC1MAPTSCN10A | |
| SCHEMBL22853204 | 0.83 | SMN1; SMN2 (0.43) | SORT1NPC1MAPTSCN10AMAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | SCN8A, SCN1A, SCN1B | DHODH 1951/4885HDAC6 428/4885LCK 1036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.