Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294604 | 1.00 | CFTR (0.46) | CFTRTAS2R14SCN8ASCN10ALMNA | |
| SCHEMBL30294684 | 0.91 | CFTR (0.48) | CFTRTAS2R14SCN8ASCN10AMAPT | |
| SCHEMBL22852810 | 0.91 | CFTR (0.48) | CFTRTAS2R14SCN8ASCN10AMAPT | |
| SCHEMBL22852863 | 0.89 | TAS2R14 (0.53) | TAS2R14SCN8ASCN10ALMNAKMT2A | |
| SCHEMBL30294567 | 0.89 | TAS2R14 (0.53) | TAS2R14SCN8ASCN10ALMNAKMT2A | |
| SCHEMBL22853395 | 0.89 | DHODH (0.49) | CFTRTAS2R14SCN8ASCN10AMAPT | |
| SCHEMBL30294511 | 0.89 | DHODH (0.49) | CFTRTAS2R14SCN8ASCN10AMAPT | |
| SCHEMBL22833864 | 0.83 | CFTR (0.50) | CFTRTAS2R14SCN8ASCN10ADHODH | |
| SCHEMBL29383454 | 0.83 | CFTR (0.50) | CFTRTAS2R14SCN8ASCN10ADHODH | |
| SCHEMBL22852849 | 0.81 | TAS2R14 (0.54) | TAS2R14DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |