Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294784 | 1.00 | MAPT (0.49) | MAPTALDH1A1KMT2AMAPK13MAPK12 | |
| SCHEMBL30294796 | 0.91 | MAPT (0.50) | MAPTALDH1A1KMT2AMAPK13MAPK12 | |
| SCHEMBL22853357 | 0.91 | MAPT (0.50) | MAPTALDH1A1KMT2AMAPK13MAPK12 | |
| SCHEMBL22852811 | 0.84 | CDC25B (0.50) | ALDH1A1MAPK14TDP1SMN1; SMN2POLB | |
| SCHEMBL30294267 | 0.84 | CDC25B (0.50) | ALDH1A1MAPK14TDP1SMN1; SMN2POLB | |
| SCHEMBL22833395 | 0.83 | KDM4E (0.46) | MAPTTDP1SMN1; SMN2POLBLMNA | |
| SCHEMBL29382578 | 0.83 | KDM4E (0.46) | MAPTTDP1SMN1; SMN2POLBLMNA | |
| SCHEMBL22852841 | 0.83 | CLCN2 (0.57) | MAPTALDH1A1KMT2AMAPK13MAPK12 | |
| SCHEMBL30294548 | 0.83 | CLCN2 (0.57) | MAPTALDH1A1KMT2AMAPK13MAPK12 | |
| SCHEMBL22853336 | 0.82 | SMN1; SMN2 (0.42) | ALDH1A1KMT2ATDP1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |