Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 1/20 | 0.57 |
| ▸ | GRIK1 | P39086 | 6/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294548 | 1.00 | CLCN2 (0.57) | CLCN2GRIK1MAPK13MAPK12MAPK11 | |
| SCHEMBL22852993 | 0.90 | KDM4E (0.54) | CLCN2GRIK1MAPK13MAPK12MAPK11 | |
| SCHEMBL30294397 | 0.90 | KDM4E (0.54) | CLCN2GRIK1MAPK13MAPK12MAPK11 | |
| SCHEMBL30294563 | 0.83 | ALDH1A1 (0.52) | CLCN2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL22852829 | 0.83 | ALDH1A1 (0.52) | CLCN2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5680871 | 0.83 | IDO1 (0.61) | GRIK1KMT2AMEN1USP2PABPC1 | |
| SCHEMBL22853397 | 0.83 | MAPT (0.49) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL30294784 | 0.83 | MAPT (0.49) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL22853082 | 0.82 | CLCN2 (0.53) | CLCN2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL30294647 | 0.82 | CLCN2 (0.53) | CLCN2MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |