Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294288 | 1.00 | P2RX7 (0.37) | P2RX7GPR6ALDH1A1HPGDTSHR | |
| SCHEMBL30294371 | 0.88 | HPGD (0.39) | P2RX7GPR6ALDH1A1HPGDTSHR | |
| SCHEMBL22853487 | 0.88 | HPGD (0.39) | P2RX7GPR6ALDH1A1HPGDTSHR | |
| SCHEMBL22853042 | 0.85 | P2RX7 (0.41) | P2RX7ALDH1A1HPGDABL1SCN10A | |
| SCHEMBL30294279 | 0.85 | P2RX7 (0.41) | P2RX7ALDH1A1HPGDABL1SCN10A | |
| SCHEMBL22853352 | 0.84 | DHODH (0.43) | P2RX7DHODH | |
| SCHEMBL30294359 | 0.84 | DHODH (0.43) | P2RX7DHODH | |
| SCHEMBL22853059 | 0.82 | P2RX7 (0.44) | P2RX7ALDH1A1HPGDTSHRHTT | |
| SCHEMBL30294481 | 0.82 | P2RX7 (0.44) | P2RX7ALDH1A1HPGDTSHRHTT | |
| SCHEMBL22853069 | 0.81 | GPR6 (0.44) | P2RX7GPR6POLQF10DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |