Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.40 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294359 | 1.00 | DHODH (0.43) | DHODHAKR1C2AKR1C1P2RX7IGF2BP2 | |
| SCHEMBL30294279 | 0.92 | P2RX7 (0.41) | DHODHP2RX7FFAR4IDH1 | |
| SCHEMBL22853042 | 0.92 | P2RX7 (0.41) | DHODHP2RX7FFAR4IDH1 | |
| SCHEMBL22853493 | 0.84 | P2RX7 (0.37) | DHODHP2RX7 | |
| SCHEMBL30294288 | 0.84 | P2RX7 (0.37) | DHODHP2RX7 | |
| SCHEMBL22853078 | 0.83 | CLCN2 (0.43) | DHODH | |
| SCHEMBL30294466 | 0.83 | CLCN2 (0.43) | DHODH | |
| SCHEMBL22853043 | 0.78 | MAPK3 (0.41) | — | |
| SCHEMBL30294640 | 0.78 | MAPK3 (0.41) | — | |
| SCHEMBL22853085 | 0.76 | AKR1C2 (0.46) | DHODHAKR1C2AKR1C1P2RX7IGF2BP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |