Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | GPR6 | P46095 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | NCS1 | P62166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294649 | 1.00 | RXFP1 (0.48) | RXFP1SCN8ASCN10ANTRK1NTRK2 | |
| SCHEMBL29382977 | 0.91 | SCN8A (0.47) | RXFP1SCN8ASCN10ANTRK1NTRK2 | |
| SCHEMBL22853425 | 0.91 | SCN8A (0.47) | RXFP1SCN8ASCN10ANTRK1NTRK2 | |
| SCHEMBL30294880 | 0.91 | SORT1 (0.44) | RXFP1SCN8ASCN10ANTRK1NTRK2 | |
| SCHEMBL30294304 | 0.90 | MEN1 (0.47) | RXFP1SCN8ASCN10ASORT1KDM4E | |
| SCHEMBL22853497 | 0.90 | MEN1 (0.47) | RXFP1SCN8ASCN10ASORT1KDM4E | |
| SCHEMBL22853481 | 0.90 | SORT1 (0.45) | RXFP1SCN8ASCN10ANTRK1NTRK2 | |
| SCHEMBL30294346 | 0.90 | SORT1 (0.45) | RXFP1SCN8ASCN10ANTRK1NTRK2 | |
| SCHEMBL22853149 | 0.88 | SORT1 (0.43) | RXFP1SCN8ASCN10ANTRK1NTRK2 | |
| SCHEMBL30294780 | 0.88 | SORT1 (0.43) | RXFP1SCN8ASCN10ANTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |