Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294304 | 1.00 | MEN1 (0.47) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL22853243 | 0.91 | SCN8A (0.47) | MAPTKDM4EALDH1A1MAPK1SORT1 | |
| SCHEMBL30294361 | 0.91 | SCN8A (0.47) | MAPTKDM4EALDH1A1MAPK1SORT1 | |
| SCHEMBL30294649 | 0.90 | RXFP1 (0.48) | KDM4ESORT1RXFP1SCN8ASCN10A | |
| SCHEMBL22853494 | 0.90 | RXFP1 (0.48) | KDM4ESORT1RXFP1SCN8ASCN10A | |
| SCHEMBL22853196 | 0.84 | SORT1 (0.43) | MEN1KMT2AMAPTKDM4EMAPK1 | |
| SCHEMBL30294814 | 0.84 | SORT1 (0.43) | MEN1KMT2AMAPTKDM4EMAPK1 | |
| SCHEMBL22852910 | 0.83 | SORT1 (0.46) | KMT2AMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL22853425 | 0.83 | SCN8A (0.47) | KDM4ESORT1RXFP1SCN8ASCN10A | |
| SCHEMBL22853186 | 0.83 | SORT1 (0.46) | KDM4EALDH1A1SMN1; SMN2SORT1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |