Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 19/20 | 1.00 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17159812 | 0.85 | CYP19A1 (0.80) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL5438954 | 0.83 | CYP19A1 (0.71) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL14414034 | 0.83 | CYP19A1 (0.71) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL305336 | 0.82 | CYP19A1 (1.00) | CYP19A1 | |
| SCHEMBL306720 | 0.81 | CYP19A1 (0.74) | CYP19A1 | |
| SCHEMBL3456043 | 0.81 | CYP19A1 (0.68) | CYP19A1CYP11B1CYP11B2HDAC1HDAC6 | |
| SCHEMBL3460891 | 0.80 | CYP19A1 (0.67) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL15688800 | 0.80 | CYP19A1 (0.71) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL3235365 | 0.78 | CYP19A1 (0.69) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL11354103 | 0.78 | CYP19A1 (0.69) | CYP19A1CYP11B1CYP11B2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104844529-A | Two functionalized ligands containing triazole heterocyclic compound and synthesis method thereof | UNIV QILU TECHNOLOGY | 2015-08-19 | — | — | CN | claimed |
| US-8003804-B2 | Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate | CIPLA LIMITED (IN) | 2011-08-23 | — | — | US | claimed |
| US-20100190997-A1 | Process for the Preparation of Letrozole | CADILA HEALTHCARE LIMITED (IN) | 2010-07-29 | — | — | US | claimed |
| US-20090270633-A1 | Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate | CIPLA LIMITED (IN) | 2009-10-29 | — | — | US | claimed |
| EP-1945618-A2 | PROCESS FOR THE PREPARATION OF LETROZOLE | CADILA HEALTHCARE LTD. (IN) | 2008-07-23 | — | — | EP | claimed |
| WO-2007107733-A1 | SYNTHESIS OF 4-[1-(4-CYANO PHENYL)-(1,2,4-TR1AZOL-1-YL)METHYL] BENZONITRILE AND 4-[1-(1H-1,2,4-TRIAZOL-1-YL)METHYLENE BENZONITRILE INTERMEDIATE | CIPLA LIMITED (IN) | 2007-09-27 | — | — | WO | claimed |
| WO-2007054964-A2 | PROCESS FOR THE PREPARATION OF LETROZOLE | CADILA HEALTHCARE LIMITED (IN) | 2007-05-18 | — | — | WO | claimed |
| US-20050209294-A1 | Process for producing 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile | M/S. IND-SWIFT LABORATORIES LIMITED (IN) | 2005-09-22 | — | — | US | claimed |
| US-5352795-A | Condensing triazolylmethylbenzonitrile with fluorobenzonitrile under basic conditions using alkali metal alkoxide | CIBA-GEIGY CORPORATION (US) | 1994-10-04 | — | — | US | claimed |
| CN-113880780-B | Benzamidine derivative, preparation method and application | 西北农林科技大学 | 2024-10-11 | — | — | CN | disclosed |
| EP-2822656-B1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | CANCER RES INST ROYAL (GB) | 2016-10-19 | — | — | EP | disclosed |
| US-9193689-B2 | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use | INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) | 2015-11-24 | — | — | US | disclosed |
| US-9150524-B2 | Pure intermediate | GENERICS [UK] LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| US-9150524-B2 | Pure intermediate | GENERICS [UK] LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| US-5703109-A | CYANOPHENYL-1,2,4-TRIAZOLE DERIVATIVE | Oy, Orion-yhtyma (FI) | 1997-12-30 | — | — | US | disclosed |
| EP-0674626-A1 | NOVEL SELECTIVE AROMATASE INHIBITING COMPOUNDS | ORION-YHTYMÄ OY (FI) | 1995-10-04 | — | — | EP | disclosed |
| CN-1093357-A | Novel selective aromatase inhibiting compounds | ORION YHTYMAE OY (FI) | 1994-10-12 | — | — | CN | disclosed |
| WO-1994013645-A1 | NOVEL SELECTIVE AROMATASE INHIBITING COMPOUNDS | Orion-Yhtymä Oy (FI) | 1994-06-23 | — | — | WO | disclosed |
| US-5006543-A | Diphenylethane derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-09 | — | — | US | disclosed |
| EP-0354689-A1 | Diphenylethane derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-02-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270633-A1 | Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate | CYP19A1, CDK14, KISS1R | CYP19A1 1/4885CYP11B1 77/4885CYP11B2 153/4885 |
| US-20050209294-A1 | Process for producing 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile | CYP19A1, NR5A1, KCNK4 | CYP19A1 1/4885CYP11B1 164/4885CYP11B2 306/4885 |
| US-20100190997-A1 | Process for the Preparation of Letrozole | CYP19A1, CYP11A1, HSD17B11 | CYP19A1 1/4885CYP11B1 5/4885CYP11B2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.