Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22526292 | 0.88 | CARM1 (0.39) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL23696009 | 0.87 | SIGMAR1 (0.36) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL24511426 | 0.85 | SAT1 (0.36) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL24508530 | 0.84 | DRD2 (0.38) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL23572087 | 0.84 | HRH3 (0.36) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL24673844 | 0.84 | DRD2 (0.35) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL22526285 | 0.83 | CARM1 (0.40) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL22856073 | 0.83 | SMN1; SMN2 (0.41) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL21107631 | 0.83 | DRD2 (0.39) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL24673860 | 0.82 | HRH3 (0.35) | DRD2HTR2AHTR2CHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192586-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |