Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.33 |
| ▸ | PTGIR | P43119 | 2/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13739581 | 1.00 | JAK2 (0.37) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL5696892 | 0.87 | ALDH1A1 (0.43) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL6256094 | 0.87 | — | — | |
| SCHEMBL17029138 | 0.87 | ALDH1A1 (0.43) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL5682344 | 0.86 | JAK2 (0.34) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL5680239 | 0.83 | ALDH1A1 (0.35) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL5682481 | 0.82 | ALDH1A1 (0.34) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL17444411 | 0.80 | SLC1A3 (0.38) | LMNASLC1A3SLC1A2SLC1A1PTGIR | |
| SCHEMBL17444410 | 0.80 | SLC1A3 (0.38) | LMNASLC1A3SLC1A2SLC1A1PTGIR | |
| SCHEMBL17449195 | 0.80 | LMNA (0.42) | JAK2JAK1TYK2JAK3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |