Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.82 |
| ▸ | FLT3 | P36888 | 6/20 | 0.82 |
| ▸ | JAK3 | P52333 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | JAK1 | P23458 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29236036 | 0.92 | JAK2 (0.70) | JAK2FLT3JAK3MAPTJAK1 | |
| SCHEMBL24426171 | 0.90 | JAK2 (0.81) | JAK2FLT3JAK3MAPTALDH1A1 | |
| SCHEMBL29236035 | 0.90 | JAK2 (0.68) | JAK2FLT3JAK3MAPTJAK1 | |
| SCHEMBL24426180 | 0.88 | JAK2 (0.77) | JAK2FLT3JAK3MAPTALDH1A1 | |
| SCHEMBL24426219 | 0.88 | FGFR4 (0.64) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL24426201 | 0.88 | JAK2 (0.64) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL28443644 | 0.87 | JAK2 (0.76) | JAK2FLT3JAK3MAPTALDH1A1 | |
| SCHEMBL28443652 | 0.87 | JAK2 (0.64) | JAK2FLT3JAK3MAPTALDH1A1 | |
| SCHEMBL29235907 | 0.87 | JAK2 (0.64) | JAK2FLT3JAK3MAPTJAK1 | |
| SCHEMBL28437348 | 0.87 | JAK2 (0.64) | JAK2FLT3JAK3MAPTJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259196-A1 | 2-AMINOPYRIMIDINE COMPOUND AND USES THEREOF | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2022-08-18 | — | — | US | claimed |
| EP-3998254-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREOF | Shenyang Pharmaceutical University (CN) | 2022-05-18 | — | — | EP | claimed |
| CN-113891881-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2022-01-04 | — | — | CN | claimed |
| US-20220259196-A1 | 2-AMINOPYRIMIDINE COMPOUND AND USES THEREOF | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2022-08-18 | — | — | US | disclosed |
| EP-3998254-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREOF | Shenyang Pharmaceutical University (CN) | 2022-05-18 | — | — | EP | disclosed |
| EP-3998254-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREOF | Shenyang Pharmaceutical University (CN) | 2022-05-18 | — | — | EP | disclosed |
| CN-113891881-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2022-01-04 | — | — | CN | disclosed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| WO-2021000884-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREOF | 沈阳药科大学 | 2021-01-07 | — | — | WO | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259196-A1 | 2-AMINOPYRIMIDINE COMPOUND AND USES THEREOF | DPYD, TPMT, TYMP | JAK2 23/4885FLT3 35/4885JAK3 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.