Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.64 |
| ▸ | FLT3 | P36888 | 5/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.59 |
| ▸ | JAK1 | P23458 | 3/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437346 | 0.90 | JAK2 (0.64) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL24426203 | 0.89 | JAK2 (0.63) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL22860801 | 0.88 | JAK2 (0.82) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL28447910 | 0.86 | JAK3 (0.65) | JAK2JAK3JAK1TYK2MTOR | |
| SCHEMBL28443652 | 0.85 | JAK2 (0.64) | JAK2FLT3JAK3MTORPTGS2 | |
| SCHEMBL28439360 | 0.84 | JAK2 (0.63) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL28439357 | 0.81 | JAK2 (0.51) | JAK2FLT3 | |
| SCHEMBL28437348 | 0.80 | JAK2 (0.64) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL29236036 | 0.80 | JAK2 (0.70) | JAK2FLT3JAK3JAK1TYK2 | |
| SCHEMBL28441098 | 0.79 | JAK2 (0.61) | JAK2FLT3MTORALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3998254-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREOF | Shenyang Pharmaceutical University (CN) | 2022-05-18 | — | — | EP | disclosed |
| CN-113891881-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2022-01-04 | — | — | CN | disclosed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |