⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977259 | 0.88 | TLR7 (0.36) | — | |
| SCHEMBL15114760 | 0.85 | — | — | |
| SCHEMBL7977343 | 0.82 | HRH3 (0.32) | — | |
| SCHEMBL23119192 | 0.79 | — | — | |
| SCHEMBL7994249 | 0.79 | — | — | |
| SCHEMBL1145591 | 0.78 | — | — | |
| SCHEMBL7971472 | 0.78 | HRH3 (0.48) | — | |
| SCHEMBL30944141 | 0.76 | HTT (0.38) | — | |
| SCHEMBL326787 | 0.76 | — | — | |
| SCHEMBL278546 | 0.75 | NOS3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086383-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2023-05-19 | — | — | WO | disclosed |
| US-10266514-B2 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180044318-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORP (US) | 2018-02-15 | — | — | US | disclosed |
| US-9822093-B2 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION (US) | 2017-11-21 | — | — | US | disclosed |
| US-20160297791-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORP (US) | 2016-10-13 | — | — | US | disclosed |
| US-9394274-B2 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION (US) | 2016-07-19 | — | — | US | disclosed |
| CN-102643267-B | The preparation method of 4-amino-2-(2,6-dioxopiperidin-3-base) isoindoline-1,3-dione compounds | CELGENE CORP. (US) | 2015-09-16 | — | — | CN | disclosed |
| US-20140256950-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2014-09-11 | — | — | US | disclosed |
| US-8785644-B2 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION (US) | 2014-07-22 | — | — | US | disclosed |
| EP-2380887-B1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORP (US) | 2013-08-07 | — | — | EP | disclosed |
| EP-1907373-B1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORP (US) | 2013-01-09 | — | — | EP | disclosed |
| CN-102643267-A | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORP | 2012-08-22 | — | — | CN | disclosed |
| CN-101253163-B | Process for preparing 4-amino-2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione compounds | CELGENE CORP | 2012-05-02 | — | — | CN | disclosed |
| EP-2380887-A1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | Celgene Corporation (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20110224440-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION | 2011-09-15 | — | — | US | disclosed |
| US-7994327-B2 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION (US) | 2011-08-09 | — | — | US | disclosed |
| CN-101253163-A | Process for preparing 4-amino-2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione compounds | CELGENE CORP (US) | 2008-08-27 | — | — | CN | disclosed |
| EP-1907373-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007005972-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2007-01-11 | — | — | WO | disclosed |
| US-20070004920-A1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION AN ORGNIZATION OF THE STATE NEW JERSEY (US) | 2007-01-04 | — | — | US | disclosed |