SCHEMBL2286299

SCHEMBL2286299

O=C(Nc1ncc(-c2ccnc(Nc3cccc(Cl)c3)n2)s1)C(F)(F)F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CAMK2D Q13557 3/20 0.54
ABL1 P00519 3/20 0.53
BCR P11274 3/20 0.53
PRKCA P17252 2/20 0.53
PRKCD Q05655 1/20 0.53
CDK2 P24941 6/20 0.51
CDK1 P06493 4/20 0.51
CCNT1 O60563 4/20 0.51
CCNA2 P20248 4/20 0.51
CDK9 P50750 4/20 0.51
CCNB1 P14635 3/20 0.51
CDK7 P50613 3/20 0.51
CCNH P51946 3/20 0.51
CCNA1 P78396 2/20 0.51
CDK4 P11802 2/20 0.49
KDR P35968 1/20 0.46
IKBKB O14920 1/20 0.44
GAA P10253 1/20 0.43
MAPT P10636 2/20 0.43
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2280988 0.89 CDK2 (0.52) CAMK2DABL1BCRPRKCAPRKCD
SCHEMBL2283687 0.87 CAMK2D (0.57) CAMK2DABL1BCRPRKCAPRKCD
SCHEMBL2288481 0.87 CCNT1 (0.52) ABL1BCRPRKCAPRKCDCDK2
SCHEMBL2287627 0.86 PIK3CG (0.56) CAMK2DABL1BCRPRKCACDK2
SCHEMBL2288575 0.80 CDK2 (0.55) CAMK2DABL1BCRPRKCAPRKCD
SCHEMBL2286391 0.80 CDK2 (0.49) CAMK2DABL1BCRPRKCAPRKCD
SCHEMBL27153366 0.80 AURKA (0.53) CDK2CDK1CCNT1CCNA2CDK9
SCHEMBL2286440 0.79 ZAP70 (0.53) PRKCAPRKCDCDK2CDK1CCNT1
SCHEMBL2287037 0.77 CDK2 (0.68) CAMK2DABL1BCRPRKCAPRKCD
SCHEMBL2289026 0.77 CAMK2D (0.62) CAMK2DABL1BCRPRKCAPRKCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110195968-A1 THIAZOLES AS FUNGICIDES BAYER CROPSCIENCE AG (DE) 2011-08-11 US disclosed
US-20090030024-A1 THIAZOLES AS FUNGICIDES BAYER CROPSCIENCE AG (DE) 2009-01-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090030024-A1 THIAZOLES AS FUNGICIDES CYP4X1, CYP4Z1, RDX CAMK2D 3550/4885ABL1 797/4885BCR 1002/4885
US-20110195968-A1 THIAZOLES AS FUNGICIDES CYP4X1, CYP4Z1, CYP3A4 CAMK2D 3704/4885ABL1 732/4885BCR 1136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.