Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92159 | 0.89 | NQO1 (0.78) | NQO1MAOBPARP10MEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL27799297 | 0.86 | NQO1 (0.74) | NQO1MAOBPARP10MEN1KMT2A | |
| SCHEMBL30776959 | 0.86 | KMT2A (0.69) | NQO1L3MBTL1MAOBPARP10PLA2G4B | |
| SCHEMBL28418500 | 0.86 | MAOB (0.62) | NQO1MAOBPARP10PLA2G4BKMT2A | |
| SCHEMBL7631521 | 0.83 | NPC1 (0.64) | L3MBTL1MAOBPARP10MEN1KMT2A | |
| Cyanide SCHEMBL28150915 | 0.82 | NQO1 (0.67) | NQO1MAOBPARP10MEN1KMT2A | |
| SCHEMBL2492122 | 0.82 | NQO1 (0.67) | NQO1MAOBALDH1A1MAPTNPC1 | |
| SCHEMBL12736285 | 0.82 | NQO1 (0.67) | NQO1MAOBALDH1A1MAPTNPC1 | |
| SCHEMBL8737704 | 0.82 | LTA4H (0.68) | NQO1MAOBPARP10MEN1KMT2A | |
| SCHEMBL12536665 | 0.81 | KMT2A (0.66) | MAOBPARP10MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110206568-A1 | PROCESS FOR THE PREPARATION OF DIARYL CARBONATES OR ARYLALKYL CARBONATES FROM DIALKYL CARBONATES | BAYER MATERIALSCIENCE AG (DE) | 2011-08-25 | — | — | US | disclosed |
| US-8003817-B2 | Process for the preparation of diaryl carbonates or arylalkyl carbonates from dialkyl carbonates | BAYER MATERIALSCIENCE AG (DE) | 2011-08-23 | — | — | US | disclosed |
| US-20080293960-A1 | Process For The Preparation Of Diaryl Carbonates Or Arylalkyl Carbonates From Dialkyl Carbonates | BAYER MATERIALSCIENCE AG (DE) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293960-A1 | Process For The Preparation Of Diaryl Carbonates Or Arylalkyl Carbonates From Dialkyl Carbonates | HDHD5, ALKBH3, AHR | NQO1 2341/4885L3MBTL1 4844/4885MAOB 2363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.