Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 11/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840557 | 0.82 | GAA (0.44) | GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL6867906 | 0.80 | POLB (0.54) | POLBGAAARPDE4APDE4B | |
| SCHEMBL7486810 | 0.80 | POLB (0.54) | POLBGAAARPDE4APDE4B | |
| SCHEMBL8561327 | 0.80 | POLB (0.73) | POLBGAAARPDE4APDE4B | |
| SCHEMBL6511189 | 0.80 | MAOB (0.55) | POLBGAAARPDE4APDE4B | |
| SCHEMBL30426714 | 0.80 | AR (0.66) | POLBGAAARPDE4APDE4B | |
| SCHEMBL30441601 | 0.80 | GAA (0.72) | POLBGAAARPDE4APDE4B | |
| SCHEMBL1162713 | 0.80 | GAA (0.72) | POLBGAAARPDE4APDE4B | |
| SCHEMBL14018654 | 0.78 | PARP10 (0.56) | POLBGAAARPDE4APDE4B | |
| SCHEMBL22719774 | 0.76 | AR (0.50) | POLBGAAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |