Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.40 |
| ▸ | TEK | Q02763 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868021 | 0.85 | HDAC8 (0.53) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL28202461 | 0.83 | HDAC8 (0.52) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL28907313 | 0.81 | CYP19A1 (0.64) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL19454747 | 0.75 | BRD4 (0.53) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL5705130 | 0.75 | CA1 (0.49) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL20812239 | 0.75 | CA1 (0.46) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL28783182 | 0.74 | HDAC8 (0.47) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL28319778 | 0.71 | FLT3 (0.67) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL19449440 | 0.71 | CA1 (0.46) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL16220810 | 0.71 | CA1 (0.68) | HDAC8HDAC6CA1CA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11654137-B2 | 3-(hydroxy)-pyridin-4(1H)-one compounds and methods of making and using the same | GEORGIA TECH RESEARCH CORPORATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-20210000811-A1 | 3-(HYDROXY)-PYRIDIN-4(1H)-ONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | GEORGIA TECH RESEARCH CORPORATION (US) | 2021-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11654137-B2 | 3-(hydroxy)-pyridin-4(1H)-one compounds and methods of making and using the same | KDM1B, KDM3A, KDM1A | HDAC8 194/4885HDAC6 2960/4885HDAC3 189/4885 |
| US-20210000811-A1 | 3-(HYDROXY)-PYRIDIN-4(1H)-ONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | KDM1B, KDM3A, KDM1A | HDAC8 194/4885HDAC6 2960/4885HDAC3 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.