Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | FNTA | P49354 | 1/20 | 0.50 |
| ▸ | FNTB | P49356 | 1/20 | 0.50 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | CLK3 | P49761 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1024738 | 0.83 | CLK1 (0.44) | POLBGAACYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29530507 | 0.83 | CLK1 (0.44) | POLBGAACYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19243792 | 0.79 | SLC22A12 (0.50) | PTGS2ALDH1A1SMN1; SMN2ARCLK1 | |
| SCHEMBL5878576 | 0.77 | CYP19A1 (0.49) | POLBGAACYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22169508 | 0.76 | POLB (1.00) | POLBGAAALDH1A1ARNPC1 | |
| SCHEMBL27151271 | 0.75 | POLB (0.68) | POLBGAAFNTAFNTBPGGT1B | |
| SCHEMBL26317308 | 0.75 | ALDH1A1 (0.42) | POLBCYP19A1ALDH1A1SMN1; SMN2CA12 | |
| SCHEMBL4766762 | 0.75 | APP (0.45) | POLBGAACYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5792344 | 0.75 | SLC6A4 (0.58) | POLBCYP19A1ALDH1A1SMN1; SMN2AR | |
| SCHEMBL9853810 | 0.75 | PTGS1 (0.54) | PTGS1PTGS2ALDH1A1SMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |