Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 11/20 | 0.61 |
| ▸ | KDM4A | O75164 | 11/20 | 0.61 |
| ▸ | KDM4D | Q6B0I6 | 11/20 | 0.61 |
| ▸ | HIF1AN | Q9NWT6 | 11/20 | 0.61 |
| ▸ | KDM2A | Q9Y2K7 | 11/20 | 0.61 |
| ▸ | KDM5B | Q9UGL1 | 9/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | KDM3B | Q7LBC6 | 9/20 | 0.49 |
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868062 | 0.88 | CA12 (0.47) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL29580908 | 0.78 | HSD17B1 (0.46) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL22867869 | 0.78 | HSD17B1 (0.46) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL22425202 | 0.72 | CYP17A1 (0.58) | SCN9ACYP17A1PTGDR2PSMB8 | |
| SCHEMBL23092683 | 0.70 | MEN1 (0.53) | CYP17A1 | |
| SCHEMBL10361607 | 0.69 | CYP17A1 (0.61) | CYP17A1PTGDR2PSMB8 | |
| SCHEMBL14076457 | 0.69 | CYP17A1 (0.54) | SCN9ACYP17A1PTGDR2PSMB8 | |
| SCHEMBL132701 | 0.68 | CYP17A1 (0.76) | CYP17A1PTGDR2PSMB8 | |
| SCHEMBL13055402 | 0.67 | CYP17A1 (0.59) | CYP17A1PTGDR2PSMB8 | |
| SCHEMBL702839 | 0.67 | CYP17A1 (0.58) | CYP17A1PTGDR2PSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3994125-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | Regeneron Pharmaceuticals, Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |