Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 15/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 14/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | HSD17B4 | P51659 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22867869 | 1.00 | HSD17B1 (0.46) | HSD17B1HSD17B2SCN9ADAOHSD17B4 | |
| SCHEMBL30359800 | 0.81 | HSD17B2 (0.44) | HSD17B1HSD17B2DAOHSD17B4 | |
| SCHEMBL29581384 | 0.79 | HSD17B2 (0.53) | HSD17B1HSD17B2DAOHSD17B4 | |
| SCHEMBL22867532 | 0.79 | HSD17B2 (0.53) | HSD17B1HSD17B2DAOHSD17B4 | |
| SCHEMBL22868063 | 0.78 | KDM6B (0.61) | SCN9ADAOKDM6BKDM4AKDM4D | |
| SCHEMBL29581651 | 0.77 | HSD17B2 (0.51) | HSD17B1HSD17B2DAOHSD17B4 | |
| SCHEMBL22868062 | 0.75 | CA12 (0.47) | SCN9ADAOKDM6BKDM4AKDM4D | |
| SCHEMBL22867907 | 0.71 | HSD17B2 (0.78) | HSD17B1HSD17B2HSD17B4 | |
| SCHEMBL30359774 | 0.71 | HSD17B2 (0.78) | HSD17B1HSD17B2HSD17B4 | |
| SCHEMBL22867810 | 0.71 | HSD17B2 (0.61) | HSD17B1HSD17B2HSD17B4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3994125-B1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMA (US) | 2025-12-24 | — | — | EP | disclosed |
| US-20240299402-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2024-09-12 | — | — | US | disclosed |
| US-11957687-B2 | Modulators of HSD17B13 and methods of use thereof | REGENERON PHARMACEUTICALS, INC. (US) | 2024-04-16 | — | — | US | disclosed |
| US-20230094341-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2023-03-30 | — | — | US | disclosed |
| EP-3994125-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | Regeneron Pharmaceuticals, Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240299402-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | HSD17B3, HSD17B11, HSD17B1 | HSD17B1 3/4885HSD17B2 5/4885SCN9A 3724/4885 |
| US-20230094341-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | HSD17B3, HSD17B11, HSD17B1 | HSD17B1 3/4885HSD17B2 5/4885SCN9A 3724/4885 |
| US-11957687-B2 | Modulators of HSD17B13 and methods of use thereof | HSD17B3, HSD17B11, HSD17B1 | HSD17B1 3/4885HSD17B2 5/4885SCN9A 3724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.