⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1091555 | 0.72 | — | — | |
| SCHEMBL15846496 | 0.71 | ALDH1A1 (0.30) | — | |
| SCHEMBL30660633 | 0.67 | — | — | |
| SCHEMBL9752696 | 0.67 | — | — | |
| SCHEMBL10413298 | 0.67 | — | — | |
| SCHEMBL4061769 | 0.67 | — | — | |
| SCHEMBL1768522 | 0.67 | — | — | |
| SCHEMBL7369739 | 0.67 | — | — | |
| SCHEMBL3153367 | 0.67 | — | — | |
| SCHEMBL2329633 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120192318-A | Pyrrolizino [2,3-c ] quinoline derivatives, synthetic method and application thereof | 中国科学院大连化学物理研究所 | 2025-06-24 | — | — | CN | disclosed |
| WO-2023086539-A2 | BCAT2 INHIBITORS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| US-10010554-B2 | Fused pyrimidines as inhibitors of P97 complex | CLEAVE BIOSCIENCES, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| EP-2875018-B1 | FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX | CLEAVE BIOSCIENCES INC (US) | 2018-02-14 | — | — | EP | disclosed |
| US-20170258795-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | CLEAVE THERAPEUTICS, INC. | 2017-09-14 | — | — | US | disclosed |
| EP-3208270-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | Cleave Biosciences, Inc. (US) | 2017-08-23 | — | — | EP | disclosed |
| US-9475824-B2 | Fused pyrimidines as inhibitors of p97 complex | CLEAVE BIOSCIENCES, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-20150239907-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | CLEAVE THERAPEUTICS, INC. | 2015-08-27 | — | — | US | disclosed |
| US-9062026-B2 | Fused pyrimidines and substituted quinazolines as inhibitors of p97 | CLEAVE BIOSCIENCES, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| EP-2875018-A1 | FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX | Cleave Biosciences, Inc. (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2000012482-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |
| WO-2000012481-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY________________ | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |
| EP-0902788-A1 | NUCLEOSIDE DERIVATIVES, AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS | CIS BIO INTERNATIONAL (FR) | 1999-03-24 | — | — | EP | disclosed |
| US-5837859-A | COPOLYMER AND NUCLEOTIDES OR HYBRIDS | CIS BIO INTERNATIONAL (FR) | 1998-11-17 | — | — | US | disclosed |
| WO-1997042207-A1 | NUCLEOSIDE DERIVATIVES, AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS | CIS BIO INTERNATIONAL (FR) | 1997-11-13 | — | — | WO | disclosed |
| EP-0691978-B1 | ELECTRONICALLY CONDUCTIVE POLYMER/NUCLEOTIDE COPOLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF | CIS BIO INT (FR) | 1997-10-08 | — | — | EP | disclosed |
| EP-0691978-A1 | ELECTRONICALLY CONDUCTIVE POLYMER/NUCLEOTIDE COPOLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF | CIS BIO INT (FR) | 1996-01-17 | — | — | EP | disclosed |
| CN-1105989-A | Tricyclic 1-aminoethylpyrrol derivative | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |
| CN-1105989-A | Tricyclic 1-aminoethylpyrrol derivative | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |
| WO-1994022889-A1 | ELECTRONICALLY CONDUCTIVE POLYMER/NUCLEOTIDE COPOLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF | CIS BIO INTERNATIONAL (FR) | 1994-10-13 | — | — | WO | disclosed |