SCHEMBL2287134

SCHEMBL2287134

O=C(NNC(=O)c1ccc(F)cc1)c1ccc(F)cc1

nearest known ligand 0.76

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.68
KMT2A Q03164 3/20 0.66
MEN1 O00255 2/20 0.66
POLB P06746 1/20 0.66
TDP1 Q9NUW8 1/20 0.66
SMN1; SMN2 Q16637 2/20 0.63
ALDH1A1 P00352 3/20 0.61
GAA P10253 3/20 0.59
RAB9A P51151 1/20 0.59
CES2 O00748 1/20 0.59
CES1 P23141 1/20 0.59
HDAC3 O15379 1/20 0.58
HDAC1 Q13547 1/20 0.58
HDAC2 Q92769 1/20 0.58
KDM4E B2RXH2 1/20 0.58
PTPN1 P18031 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31456327 0.89 TP53 (0.60) MAOAKMT2AMEN1POLBTDP1
SCHEMBL13178144 0.86 SMN1; SMN2 (0.56) MAOAKMT2AMEN1POLBTDP1
SCHEMBL23539571 0.85 ALDH1A1 (0.63) MAOAKMT2AMEN1POLBTDP1
SCHEMBL14527268 0.85 CTDSP1 (0.78) KMT2AMEN1POLBTDP1SMN1; SMN2
SCHEMBL6142664 0.85 PTPN1 (0.59) MAOAKMT2AMEN1POLBTDP1
SCHEMBL20528632 0.85 CA1 (0.62) MAOAKMT2AMEN1POLBTDP1
SCHEMBL5127523 0.84 MEN1 (0.59) KMT2AMEN1SMN1; SMN2ALDH1A1RAB9A
SCHEMBL22288978 0.84 ALDH1A1 (0.58) MAOAKMT2AMEN1POLBTDP1
SCHEMBL16057167 0.83 MAOA (0.51) MAOAKMT2AMEN1POLBTDP1
SCHEMBL14527350 0.82 HDAC1 (0.62) MAOAPOLBSMN1; SMN2ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9704997-B2 Photopatternable materials and related electronic devices and methods FLEXTERRA, INC. (US) 2017-07-11 US disclosed
US-20160190337-A1 Photopatternable Materials and Related Electronic Devices and Methods USINVEST LLC 2016-06-30 US disclosed
US-9190493-B2 Photopatternable materials and related electronic devices and methods POLYERA CORPORATION (US) 2015-11-17 US disclosed
US-20150021597-A1 Photopatternable Materials and Related Electronic Devices and Methods USINVEST LLC 2015-01-22 US disclosed
WO-2015009768-A1 PHOTOPATTERNABLE MATERIALS AND RELATED ELECTRONIC DEVICES AND METHODS POLYERA CORPORATION (US) 2015-01-22 WO disclosed
US-20110198988-A1 ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING ELEMENT, LIGHTING DEVICE, AND ELECTRONIC DEVICE INCLUDING THE ORGANOMETALLIC COMPLEX SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-08-18 US disclosed
US-20110198988-A1 ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING ELEMENT, LIGHTING DEVICE, AND ELECTRONIC DEVICE INCLUDING THE ORGANOMETALLIC COMPLEX SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-08-18 US disclosed
US-20110198988-A1 ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING ELEMENT, LIGHTING DEVICE, AND ELECTRONIC DEVICE INCLUDING THE ORGANOMETALLIC COMPLEX SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110198988-A1 ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING ELEMENT, LIGHTING DEVICE, AND ELECTRONIC DEVICE INCLUDING THE ORGANOMETALLIC COMPLEX INTS9, MCM4, INTS6 MAOA 4298/4885KMT2A 2490/4885MEN1 194/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.