Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 7/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 7/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 7/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22874723 | 0.88 | NPC1 (0.46) | NPC1GNAI3GNAO1GNAI1CACNA1B | |
| SCHEMBL7919921 | 0.84 | NPC1 (0.48) | NPC1GNAI3GNAO1GNAI1MEN1 | |
| SCHEMBL22875166 | 0.83 | NPC1 (0.44) | NPC1GNAI3GNAO1GNAI1CACNA1B | |
| SCHEMBL14147220 | 0.82 | NPC1 (0.47) | NPC1GNAI3GNAO1GNAI1MEN1 | |
| SCHEMBL22874744 | 0.82 | POLB (0.42) | NPC1GNAI3GNAO1GNAI1CACNA1B | |
| SCHEMBL19645417 | 0.81 | GNAI3 (0.49) | NPC1GNAI3GNAO1GNAI1CACNA1B | |
| SCHEMBL23551094 | 0.81 | NPC1 (0.46) | NPC1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL18232472 | 0.81 | NPC1 (0.46) | NPC1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL22874721 | 0.81 | GNAI3 (0.57) | NPC1GNAI3GNAO1GNAI1MEN1 | |
| SCHEMBL25075495 | 0.80 | NPC1 (0.42) | NPC1GNAI3GNAO1GNAI1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | C4 THERAPEUTICS, INC. (US) | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | CRBN, IKZF1, IKZF3 | NPC1 2155/4885GNAI3 1551/4885GNAO1 1521/4885 |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | CRBN, IKZF1, IKZF3 | NPC1 2645/4885GNAI3 2181/4885GNAO1 1777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.