Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22874752 | 0.83 | NPC1 (0.44) | NPC1GNAI3GNAO1GNAI1DPP8 | |
| SCHEMBL18330354 | 0.82 | GNAI3 (0.51) | NPC1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL26297821 | 0.80 | GNAI3 (0.51) | NPC1GNAI3GNAO1GNAI1DPP8 | |
| SCHEMBL11981636 | 0.79 | NPC1 (0.47) | NPC1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL27429180 | 0.79 | GNAI3 (0.60) | NPC1GNAI3GNAO1GNAI1ITGB3 | |
| SCHEMBL21871765 | 0.79 | HSD11B1 (0.47) | NPC1GNAI3GNAO1GNAI1DPP8 | |
| SCHEMBL19681628 | 0.79 | NPC1 (0.38) | NPC1GNAI3GNAO1GNAI1DPP8 | |
| SCHEMBL22874747 | 0.78 | NPC1 (0.53) | NPC1GNAI3GNAO1GNAI1ITGB3 | |
| SCHEMBL4487574 | 0.77 | EPHX2 (0.51) | NPC1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL19021775 | 0.77 | GNAI3 (0.50) | GNAI3GNAO1GNAI1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | C4 THERAPEUTICS, INC. (US) | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | CRBN, IKZF1, IKZF3 | NPC1 2155/4885GNAI3 1551/4885GNAO1 1521/4885 |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | CRBN, IKZF1, IKZF3 | NPC1 2645/4885GNAI3 2181/4885GNAO1 1777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.