Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17285928 | 0.87 | KDM4E (0.38) | KDM4EPIK3CDCNR1CNR2NAAA | |
| SCHEMBL17284567 | 0.85 | KDM4E (0.38) | KDM4EPIK3CDCNR1CNR2NQO2 | |
| SCHEMBL17281979 | 0.82 | KDM4E (0.35) | KDM4EPIK3CDCNR1CNR2NQO2 | |
| SCHEMBL22878344 | 0.75 | ADRA1B (0.41) | PIK3CD | |
| SCHEMBL10778747 | 0.74 | HRH3 (0.43) | KDM4EPIK3CD | |
| SCHEMBL22878356 | 0.73 | KEAP1 (0.47) | KDM4E | |
| SCHEMBL16377754 | 0.72 | KDM4E (0.46) | KDM4EPIK3CDCNR1CNR2NAAA | |
| SCHEMBL7625818 | 0.72 | CXCR4 (0.44) | KDM4EPIK3CD | |
| SCHEMBL17789613 | 0.71 | PIK3CD (0.50) | KDM4EPIK3CDCNR1CNR2NAAA | |
| SCHEMBL18672857 | 0.70 | PIK3CD (0.49) | KDM4EPIK3CDCNR1CNR2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145929-B1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-13 | — | — | EP | disclosed |