Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12377117 | 0.91 | SCN3A (0.59) | MEN1KMT2ACA1SCN3ASCN9A | |
| SCHEMBL12377138 | 0.88 | MEN1 (0.48) | MEN1KMT2AALDH1A1CA1SCN3A | |
| SCHEMBL12377113 | 0.88 | CA1 (0.49) | MEN1KMT2AALDH1A1CA1SCN3A | |
| SCHEMBL12377114 | 0.87 | MEN1 (0.50) | MEN1KMT2AALDH1A1CA1SCN3A | |
| SCHEMBL3159101 | 0.86 | SCN3A (0.61) | MEN1KMT2AALDH1A1CA1SCN3A | |
| SCHEMBL12377124 | 0.85 | MEN1 (0.57) | MEN1KMT2AALDH1A1CA1SCN3A | |
| SCHEMBL12377120 | 0.84 | SCN3A (0.62) | MEN1KMT2AALDH1A1SCN3ASCN9A | |
| SCHEMBL2286874 | 0.83 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1SCN3ASCN9A | |
| SCHEMBL27710954 | 0.83 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1CA1SCN3A | |
| SCHEMBL12377110 | 0.82 | SCN9A (0.49) | SCN3ASCN9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101238109-B | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INC. (US) | 2011-12-14 | — | — | CN | disclosed |
| US-7989481-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-02 | — | — | US | disclosed |
| US-7989481-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-02 | — | — | US | disclosed |
| US-7989481-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-02 | — | — | US | disclosed |
| US-20090326023-A1 | Indane Derivatives as Modulators of ION Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090326023-A1 | Indane Derivatives as Modulators of ION Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090326023-A1 | Indane Derivatives as Modulators of ION Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-12-31 | — | — | US | disclosed |
| US-7605174-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-20 | — | — | US | disclosed |
| US-7605174-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-20 | — | — | US | disclosed |
| US-7605174-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-20 | — | — | US | disclosed |
| CN-101238109-A | Indane derivatives as modulators of ion channels | VERTEX PHARMA (US) | 2008-08-06 | — | — | CN | disclosed |
| US-20070117801-A1 | Indane derivatives as modulator of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2007-05-24 | — | — | US | disclosed |
| US-20070117801-A1 | Indane derivatives as modulator of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2007-05-24 | — | — | US | disclosed |
| US-20070117801-A1 | Indane derivatives as modulator of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326023-A1 | Indane Derivatives as Modulators of ION Channels | KCNJ2, TRPV1, KCNJ1 | MEN1 2382/4885KMT2A 2997/4885ALDH1A1 1485/4885 |
| US-20070117801-A1 | Indane derivatives as modulator of ion channels | KCNJ2, TRPV1, KCNJ1 | MEN1 2271/4885KMT2A 2930/4885ALDH1A1 1510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.