Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12377138 | 0.85 | MEN1 (0.48) | SCN9ASCN3ASCN5A | |
| SCHEMBL12377118 | 0.83 | LMNA (0.54) | SCN9ASCN3APKM | |
| SCHEMBL2287872 | 0.82 | MEN1 (0.61) | SCN9ASCN3APKM | |
| SCHEMBL12377113 | 0.81 | CA1 (0.49) | SCN9ASCN3APKMSCN5A | |
| SCHEMBL12377109 | 0.81 | SCN1A (0.47) | SCN9ASCN3APKMSCN5A | |
| SCHEMBL12377120 | 0.80 | SCN3A (0.62) | SCN9ASCN3APKM | |
| SCHEMBL12377107 | 0.79 | SCN9A (0.47) | SCN9ASCN3ASCN5A | |
| SCHEMBL2286874 | 0.79 | ALDH1A1 (0.47) | SCN9ASCN3APKM | |
| SCHEMBL27710954 | 0.79 | ALDH1A1 (0.47) | SCN3APKM | |
| SCHEMBL12377124 | 0.79 | MEN1 (0.57) | SCN9ASCN3APKMSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989481-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-02 | — | — | US | disclosed |
| US-7989481-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-02 | — | — | US | disclosed |
| US-20090326023-A1 | Indane Derivatives as Modulators of ION Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090326023-A1 | Indane Derivatives as Modulators of ION Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326023-A1 | Indane Derivatives as Modulators of ION Channels | KCNJ2, TRPV1, KCNJ1 | SCN9A 131/4885SCN3A 63/4885PKM 2659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.