Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 16/20 | 0.48 |
| ▸ | IDH2 | P48735 | 15/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18459269 | 0.88 | IDH1 (0.64) | IDH1IDH2 | |
| SCHEMBL18459593 | 0.88 | IDH1 (0.64) | IDH1IDH2 | |
| SCHEMBL22879074 | 0.87 | IDH1 (0.62) | IDH1IDH2ACHETLR9 | |
| SCHEMBL20289767 | 0.86 | IDH1 (0.63) | IDH1IDH2 | |
| SCHEMBL20289762 | 0.83 | IDH1 (0.65) | IDH1IDH2 | |
| SCHEMBL18459563 | 0.82 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL21518019 | 0.81 | IDH1 (0.61) | IDH1IDH2 | |
| SCHEMBL18459835 | 0.81 | IDH1 (0.61) | IDH1IDH2 | |
| SCHEMBL21517986 | 0.81 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL18459834 | 0.81 | IDH1 (0.62) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3763717-A1 | PYRIDO[4,3-D][1,3]OXAZIN-2-ONE AND PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | ELI LILLY AND CO. (US) | 2021-01-13 | — | — | EP | disclosed |