Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 20/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19659613 | 0.97 | OPRM1 (0.48) | OPRM1 | |
| SCHEMBL30587637 | 0.85 | KDM4E (0.49) | OPRM1 | |
| SCHEMBL18366625 | 0.85 | KDM4E (0.49) | OPRM1 | |
| SCHEMBL19658681 | 0.84 | KDM5A (0.35) | OPRM1 | |
| SCHEMBL18366620 | 0.82 | KDM4E (0.49) | OPRM1 | |
| SCHEMBL30587476 | 0.80 | ALDH1A1 (0.43) | OPRM1 | |
| SCHEMBL18366624 | 0.80 | ALDH1A1 (0.43) | OPRM1 | |
| SCHEMBL18366619 | 0.77 | ALDH1A1 (0.43) | OPRM1 | |
| SCHEMBL18366622 | 0.73 | CYP17A1 (0.42) | — | |
| SCHEMBL30587514 | 0.73 | CYP17A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |