Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18366172 | 0.79 | RIPK1 (0.39) | RIPK1PLAT | |
| SCHEMBL18366231 | 0.78 | RIPK1 (0.38) | RIPK1PLAT | |
| SCHEMBL19658983 | 0.78 | RIPK1 (0.45) | RIPK1PLAT | |
| SCHEMBL18367465 | 0.77 | RIPK1 (0.44) | RIPK1PLAT | |
| SCHEMBL18366173 | 0.77 | RIPK1 (0.44) | RIPK1PLAT | |
| SCHEMBL18365806 | 0.77 | RIPK1 (0.44) | RIPK1PLAT | |
| SCHEMBL18366331 | 0.77 | RIPK1 (0.44) | RIPK1PLAT | |
| SCHEMBL18366332 | 0.77 | RIPK1 (0.44) | RIPK1PLAT | |
| SCHEMBL22888314 | 0.75 | RIPK1 (0.52) | RIPK1 | |
| SCHEMBL19655837 | 0.75 | RIPK1 (0.52) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |