Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367852 | 0.83 | JAK2 (0.41) | ALDH1A1SMN1; SMN2JAK2JAK1GAA | |
| SCHEMBL24370916 | 0.72 | HAVCR2 (0.38) | JAK2 | |
| SCHEMBL18366710 | 0.70 | NUDT1 (0.56) | ALDH1A1L3MBTL1JAK1 | |
| SCHEMBL24996360 | 0.68 | NUDT1 (0.32) | — | |
| SCHEMBL14736601 | 0.66 | PDE10A (0.42) | SMN1; SMN2JAK2TP53JAK1 | |
| SCHEMBL18341116 | 0.63 | AHR (0.49) | SMN1; SMN2JAK1 | |
| SCHEMBL19658956 | 0.62 | PARP1 (0.39) | ALDH1A1JAK2L3MBTL1JAK1 | |
| SCHEMBL22439076 | 0.62 | KDM4E (0.43) | ALDH1A1TP53L3MBTL1GAA | |
| SCHEMBL25305429 | 0.61 | RAB9A (0.40) | ALDH1A1SMN1; SMN2JAK2TP53L3MBTL1 | |
| SCHEMBL12986141 | 0.61 | BRD4 (0.55) | BRD4ALDH1A1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |