Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 5/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25338800 | 0.81 | RIPK1 (0.40) | RIPK1P2RX3P2RX2KMOPIK3CA | |
| SCHEMBL22888344 | 0.81 | NOTUM (0.40) | RIPK1KMT2ALCKKMOHTR2A | |
| SCHEMBL25337551 | 0.80 | RIPK1 (0.40) | RIPK1NT5E | |
| SCHEMBL25337436 | 0.79 | RIPK1 (0.39) | RIPK1NT5E | |
| SCHEMBL24851750 | 0.79 | PDPK1 (0.34) | RIPK1NT5EHTR2AHTR2CHTR2B | |
| SCHEMBL19659345 | 0.78 | HTR2A (0.37) | RIPK1KMT2ALCKKMOHTR2A | |
| SCHEMBL20262385 | 0.78 | RIPK1 (0.49) | RIPK1KMO | |
| SCHEMBL30587568 | 0.78 | RIPK1 (0.48) | RIPK1KMT2ALCKMAPK1SIRT6 | |
| SCHEMBL29989131 | 0.77 | ASPH (0.41) | RIPK1P2RX3P2RX2KMOMAPK1 | |
| SCHEMBL24851097 | 0.76 | HTR2A (0.35) | KMOCDK2NT5EHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |