Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 5/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22890405 | 0.83 | ALDH1A1 (0.43) | HTTPOLBLMNANCOA1SMN1; SMN2 | |
| SCHEMBL22889930 | 0.78 | LRRK2 (0.43) | HTTPOLBSMN1; SMN2KDM4EMAPT | |
| SCHEMBL22890216 | 0.75 | ALDH1A1 (0.49) | HTTSMN1; SMN2KDM4EMAPTALOX15 | |
| SCHEMBL22890418 | 0.75 | KDM4E (0.39) | NCOA1SMN1; SMN2NCOA3KDM4EALOX15 | |
| SCHEMBL29741169 | 0.75 | ALDH1A1 (0.49) | HTTSMN1; SMN2KDM4EMAPTALOX15 | |
| SCHEMBL22889980 | 0.74 | KDM4E (0.37) | KDM4EALOX15HSD17B10ALDH1A1GAA | |
| SCHEMBL22889967 | 0.72 | LRRK2 (0.46) | POLBKDM4EALOX15HSD17B10ALDH1A1 | |
| SCHEMBL22890391 | 0.72 | XDH (0.38) | HTTPOLBLMNANCOA1SMN1; SMN2 | |
| SCHEMBL31214298 | 0.72 | XDH (0.38) | HTTPOLBLMNANCOA1SMN1; SMN2 | |
| SCHEMBL22890491 | 0.71 | LRRK2 (0.43) | KDM4EALOX15HSD17B10L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |