Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 6/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 3/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14800443 | 0.86 | CYP4F2 (0.42) | RXRARXRBRXRGRETCYP4F2 | |
| SCHEMBL14800689 | 0.86 | RXRA (0.37) | RXRARXRBRXRGRETCYP4F2 | |
| SCHEMBL18369828 | 0.85 | RXRA (0.41) | RXRARXRBRXRGRETCYP4F2 | |
| SCHEMBL21198696 | 0.84 | CYP4F2 (0.39) | RXRARXRBRXRGRETCYP4F2 | |
| SCHEMBL29644003 | 0.83 | RET (0.33) | RXRARXRBRXRGRETCYP4F2 | |
| SCHEMBL22890350 | 0.83 | RET (0.33) | RXRARXRBRXRGRETCYP4F2 | |
| SCHEMBL18370091 | 0.83 | AR (0.36) | RXRARXRBRXRGRETCYP4F2 | |
| SCHEMBL21217456 | 0.83 | RET (0.37) | RXRARXRBRXRGRETCYP4F2 | |
| SCHEMBL177354 | 0.83 | CYP11B2 (0.37) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL24610343 | 0.81 | GAA (0.47) | RXRARXRBRXRGRETCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |