Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22892312 | 0.93 | ADAMTS5 (0.57) | KMT2AMAPTSMN1; SMN2GAAADAMTS5 | |
| SCHEMBL22892324 | 0.91 | CCR1 (0.50) | KMT2AMAPTSMN1; SMN2GAAADAMTS5 | |
| SCHEMBL19002660 | 0.87 | KMT2A (0.53) | KMT2AMAPTSMN1; SMN2GAAMEN1 | |
| SCHEMBL22892278 | 0.86 | ADAMTS5 (0.53) | KMT2AADAMTS5MEN1ADAMTS4CCR1 | |
| SCHEMBL22892242 | 0.85 | CCR1 (0.62) | KMT2AMAPTSMN1; SMN2GAAADAMTS5 | |
| SCHEMBL22892237 | 0.85 | KMT2A (0.53) | KMT2AMAPTSMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL22892381 | 0.82 | ADAMTS5 (0.61) | KMT2AADAMTS5MEN1ADAMTS4CCR1 | |
| SCHEMBL4171024 | 0.82 | CCR1 (0.51) | KMT2AMAPTSMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL22892271 | 0.81 | CCR1 (0.53) | KMT2AADAMTS5MEN1ADAMTS4CCR1 | |
| SCHEMBL19002658 | 0.81 | MAPT (0.57) | KMT2AMAPTSMN1; SMN2GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468955-B1 | 5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2021-01-06 | — | — | EP | disclosed |