Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 8/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22892267 | 0.91 | KMT2A (0.53) | CCR1ALKADAMTS5KMT2AGAA | |
| SCHEMBL22892381 | 0.87 | ADAMTS5 (0.61) | CCR1ALKADAMTS5KMT2ARAB9A | |
| SCHEMBL22892312 | 0.87 | ADAMTS5 (0.57) | CCR1ALKADAMTS5KMT2AGAA | |
| SCHEMBL22892278 | 0.85 | ADAMTS5 (0.53) | CCR1ALKADAMTS5KMT2AMEN1 | |
| SCHEMBL22892242 | 0.85 | CCR1 (0.62) | CCR1ALKADAMTS5KMT2AGAA | |
| SCHEMBL12765632 | 0.82 | CCR1 (0.65) | CCR1ALKRAB9A | |
| SCHEMBL19002660 | 0.81 | KMT2A (0.53) | KMT2AGAAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL22892271 | 0.81 | CCR1 (0.53) | CCR1ALKADAMTS5KMT2AMEN1 | |
| SCHEMBL22892289 | 0.80 | ALK (0.48) | CCR1ALKADAMTS5KMT2ASMN1; SMN2 | |
| SCHEMBL22892237 | 0.80 | KMT2A (0.53) | CCR1ALKKMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468955-B1 | 5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2021-01-06 | — | — | EP | disclosed |