Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25162363 | 0.88 | DDB1 (0.38) | DDB1CRBN | |
| SCHEMBL23572084 | 0.85 | DDB1 (0.43) | DDB1CRBN | |
| SCHEMBL24779909 | 0.85 | DDB1 (0.43) | DDB1CRBN | |
| SCHEMBL23946165 | 0.85 | DDB1 (0.38) | DDB1CRBN | |
| SCHEMBL23945944 | 0.85 | DDB1 (0.36) | DDB1CRBNOPRM1OPRL1 | |
| SCHEMBL22526738 | 0.84 | OXER1 (0.36) | DDB1CRBN | |
| SCHEMBL25108271 | 0.84 | DDB1 (0.42) | DDB1CRBNDAOOPRM1OPRL1 | |
| SCHEMBL23744778 | 0.84 | DDB1 (0.42) | DDB1CRBNDAOOPRM1OPRL1 | |
| SCHEMBL25110211 | 0.84 | DDB1 (0.42) | DDB1CRBNDAOOPRM1OPRL1 | |
| SCHEMBL24673887 | 0.83 | SLC6A4 (0.36) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188948-A1 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| WO-2021007307-A1 | BCL-2 PROTEIN INHIBITORS | RECURIUM IP HOLDINGS, LLC (US) | 2021-01-14 | — | — | WO | disclosed |