Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24735999 | 0.86 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL24735981 | 0.85 | NPC1 (0.48) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL24736141 | 0.83 | LMNA (0.52) | SMN1; SMN2LMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL5370889 | 0.80 | MTNR1A (0.54) | KMT2AMEN1ESR1ESR2 | |
| SCHEMBL27406074 | 0.80 | SYK (0.52) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL27406072 | 0.80 | SYK (0.52) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL6531538 | 0.80 | SYK (0.52) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL20995947 | 0.78 | KMT2A (0.50) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL28491869 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL27560649 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011873-A1 | BORON-CONTAINING RHO KINASE INHIBITORS | PERCIPIAD, INC. (US) | 2021-01-21 | — | — | WO | disclosed |