Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 15/20 | 0.41 |
| ▸ | MDM4 | O15151 | 10/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900445 | 0.91 | BRD4 (0.41) | MDM2MDM4DGAT1QPCTBRD4 | |
| SCHEMBL22900505 | 0.87 | QPCT (0.38) | MDM2MDM4QPCTFAAH | |
| SCHEMBL22900354 | 0.86 | BRD4 (0.38) | MDM2MDM4DGAT1QPCTBRD4 | |
| SCHEMBL22900491 | 0.84 | BRD4 (0.36) | MDM2MDM4DGAT1QPCTBRD4 | |
| SCHEMBL22900484 | 0.83 | BRD4 (0.44) | MDM2QPCTBRD4BRD2BRD3 | |
| SCHEMBL22900458 | 0.83 | BRD2 (0.38) | DGAT1QPCTBRD4BRD2BRD3 | |
| SCHEMBL22900518 | 0.81 | QPCT (0.33) | DGAT1QPCTBRD4BRD2BRD3 | |
| SCHEMBL22900485 | 0.80 | ALDH1A1 (0.43) | QPCT | |
| SCHEMBL22900418 | 0.79 | QPCT (0.36) | DGAT1QPCTBRD4CREBBP | |
| SCHEMBL22900185 | 0.78 | BRD4 (0.38) | MDM2MDM4BRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009068-A1 | N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME | SCENIC IMMUNOLOGY B.V. (NL) | 2021-01-21 | — | — | WO | disclosed |