Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.44 |
| ▸ | BRD2 | P25440 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900645 | 0.87 | BRD4 (0.41) | BRD4BRD3BRD2CREBBPMAPT | |
| SCHEMBL22900445 | 0.87 | BRD4 (0.41) | BRD4BRD3BRD2CREBBPQPCT | |
| SCHEMBL22900354 | 0.87 | BRD4 (0.38) | BRD4BRD3BRD2CREBBPQPCT | |
| SCHEMBL22900458 | 0.85 | BRD2 (0.38) | BRD4BRD3BRD2CREBBPQPCT | |
| SCHEMBL22900491 | 0.84 | BRD4 (0.36) | BRD4BRD3BRD2CREBBPQPCT | |
| SCHEMBL22900452 | 0.83 | MDM2 (0.41) | BRD4BRD3BRD2CREBBPQPCT | |
| SCHEMBL22900485 | 0.82 | ALDH1A1 (0.43) | MEN1KMT2AL3MBTL1QPCTKDM4E | |
| SCHEMBL22900418 | 0.81 | QPCT (0.36) | BRD4CREBBPQPCT | |
| SCHEMBL22900518 | 0.80 | QPCT (0.33) | BRD4BRD3BRD2CREBBPQPCT | |
| SCHEMBL22900181 | 0.78 | QPCT (0.52) | BRD4BRD3BRD2CREBBPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009068-A1 | N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME | SCENIC IMMUNOLOGY B.V. (NL) | 2021-01-21 | — | — | WO | disclosed |