Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900783 | 0.85 | JAK1 (0.54) | JAK1GPR119CDK2CCNT1CDK1 | |
| SCHEMBL29926869 | 0.85 | JAK1 (0.54) | JAK1GPR119CDK2CCNT1CDK1 | |
| SCHEMBL22900807 | 0.82 | NSD2 (0.49) | GPR119NSD2PIK3CDALDH1A1NPC1 | |
| SCHEMBL3776834 | 0.82 | NSD2 (0.49) | GPR119CDK2CDK1CDK4CCND1 | |
| SCHEMBL25330388 | 0.81 | JAK1 (0.52) | JAK1GPR119CDK2MAPK8MAPK9 | |
| SCHEMBL25330394 | 0.81 | JAK1 (0.52) | JAK1GPR119CDK2MAPK8MAPK9 | |
| SCHEMBL26918653 | 0.81 | NSD2 (0.52) | JAK1GPR119NSD2PIK3CDALDH1A1 | |
| SCHEMBL22900827 | 0.81 | CDK2 (0.55) | JAK1CDK2CCNT1CDK1CDK4 | |
| SCHEMBL3774992 | 0.77 | GPR119 (0.57) | GPR119NSD2ALDH1A1NPC1MAPT | |
| SCHEMBL16797325 | 0.77 | GPR119 (0.52) | GPR119CDK2MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11472791-B2 | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors | INCYTE CORPORATION (US) | 2022-10-18 | — | — | US | disclosed |
| US-20210017156-A1 | PYRAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017156-A1 | PYRAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | CDK2, CDK2AP2, CDK4 | JAK1 500/4885GPR119 3440/4885CDK2 1/4885 |
| US-11472791-B2 | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors | CDK2, CDK2AP2, CDK4 | JAK1 500/4885GPR119 3440/4885CDK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.